Biomedical Engineering Reference
In-Depth Information
Chapter 10
GUIDANCE OF CELL ADHESION,
ALIGNMENT, INFILTRATION, AND
DIFFERENTIATION ON ELECTROSPUN
NANOFIBROUS SCAFFOLDS
Sang Jin Lee
*
and James J. Yoo
Wake Forest Institute for Regenerative Medicine,
Wake Forest University Health Sciences Medical Center Boulevard,
Winston-Salem, North Carolina 27157, USA
*sjlee@wfubmc.edu
The interactions between cells and the extracellular matrix (ECM)
are fundamental processes that govern signaling for cell adhe-
sion, alignment, migration, and differentiation. Electrospun scaf-
folds are a novel tool that provides a nanofibrous architecture
that mimics ECM's three-dimensional environment. As such, scaf-
folds generated by electrospinning can be used to observe and
understandcellularbehaviorsinanano-scaledconfiguration.This
chapter illustrates methods in which guidance of cell adhesion,
alignment, infiltration, and differentiation on electrospun nanofi-
brousscaffoldscanbemeasured.Inaddition,weprovideevidence
that these cellular behaviors can be controlled by varying electro-
spinning fabrication parameters.
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