Biomedical Engineering Reference
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acid from the cross-linked HA gels. The effects of HA degradation
on the productions of tissue-type plasminogen activator and plas-
minogen activator inhibitor-1 were measured to develop a com-
bined adhesion barrier and drug delivery system for prevention of
postoperativeperitonealadhesions.Plasminogenactivatorandplas-
minarerelatedtocellmigration,tissueadhesionandconnectivetis-
sue remodeling according to degradation of implanted HA scaffolds
aftersurgery.Particlesofcross-linkedHAhydrogelswerealsofabri-
cated through aldehyde chemistry using a sodium bis(2-ethylhexyl)
sulfosuccinate/
iso
-octanereversemicellesystemforpotentialappli-
cation in vocal fold regeneration and poly(lactic-
co
-glycolic acid)
nanoparticle dispersion in aldehyde- and ADH -modified HA and
then combined these two particles via a double-barreled syringe
for an adhesion barrier combined with drug delivery.
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,
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These HA
gel particles formed a flexible and durable hydrogel through their
physical interactions. The HA particles showed prolonged
in vivo
residence time, temporal release of therapeutics, and matching vis-
coelasticity for use as a scaffold for vocal fold tissue engineering.
As a hybrid type of HA hydrogels, HA-aldehyde was coupled with
ADH-grafted PVA and the obtained HA-PVA hydrogel was tested for
bone tissue engineering by adding bone morphogenetic protein-2
(BMP-2) (Fig. 9.23).
75
Figure 9.23.
DerivativesofHA-NH
2
andHA-SHforMichael-typeaddition
reactions.
33
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