Biomedical Engineering Reference
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Figure 9.18. Synthesis of methacrylated lactide HA63 (HEMA = 2-
hydroxyethyl methacrylate, Me = methacrylate, LA = lactic acid, DMAP =
dimethylaminopyridine, TEA = triethylamine, DCC = dicyclohexylcarbodi-
imide,TBA = tetrabutylammonium) 52 .
Mixing the Zn-HA solution and BDNF with His and a cross-linking
peptide with His at both termini (CLP), solutions turned automati-
cally into an HA hydrogel.
In situ HA hydrogels by enzymes were fabricated by employ-
ing HA-tyramine (HA-Tyr) conjugates in the presence of hydrogen
 
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