Biomedical Engineering Reference
In-Depth Information
Figure 8.7.
Chemical structure of photoactive PVA. Pendant hydroxyl
groups were converted to photopolymerizable groups by reaction with
aminobutyraldehyde diethyl acetal.
8.3.2.3 Photo-cross-linkable poly(hydroxyl esters)
Poly(hydroxyl esters), such as PLA, PGA, and PCL, are among
the most thoroughly investigated synthetic biomaterials.
103
,
104
-
110
However, poly(a-hydroxyl esters) are highly crystalline polyesters
that lack modifiable side groups, which could be used to facilitate
better material-cell interactions.
105
-
110
Several investigators have
combined degradable PLA and photopolymerization technology to
manipulate the backbone with amino acids to allow for further
functionalization.
109
,
110
PLA films have also been surface-grafted
with polyacrylic acid (PAA) and poly(acrylamide) using photopoly-
merization in an attempt to generate a bioactive surface with rapid
degradation.
108
Search WWH ::
Custom Search