Biomedical Engineering Reference
In-Depth Information
Chapter 6
ENZYMATICALLY TRIGGERED IN SITU
GEL-FORMING BIOMATERIALS FOR
REGENERATIVE MEDICINE
Yoon Ki Joung, Kyung Min Park, and Ki Dong Park *
Department of Molecular Science and Technology,
Ajou University, San 5, Woncheon, Yeongtong,
Suwon 443-749, South Korea
*kdp@ajou.ac.kr
Enzymatically triggered hydrogels formed in situ are emerging
biomaterials that may have applications as injectable scaffolds
for regenerative medicine. Although in situ formation is attrac-
tivefortissueregeneration,duetotheinjectablefunctionenabling
noninvasive therapy, there are many problems to be solved
before they can be used clinically. Utilizing enzymes in hydroge-
lation might overcome the problems of hydrogels formed in situ .
Recent examples of these studies include peroxidase, transg-
lutaminase, phosphatase, and others. Enzyme-triggered hydro-
gels show predominant properties in rapid gelation and con-
trolled mechanical strength, compared with existing hydrogels
formed in situ . Therefore, the enzyme-triggered hydrogels have
significant promise as noninvasive injectable scaffolds for tissue
regeneration.
 
 
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