Biomedical Engineering Reference
In-Depth Information
E-cell
E-cell
I-cell
c
e
=5nS
c
i
1
2
3
1
3
2
<5nS
>5nS
Figure 7.3:
All-or-none inhibition of bursting by strength of inhibition.
E-cell
E-cell
I-cell
c
e
=5nS
c
i
=10nS
1
2
3
>10mS
3
1
2
<10mS
Figure 7.4:
All-or-none inhibition of bursting by delays.
enough, Cell 3 could then reinitiate firing in Cell 1 after it has repolarized. In this way, a simple neural
circuit, possibility composed of many cells, could have some natural cycle of firing.
To modulate the rate of the cycle, consider adding an interneuron, as in the right panel of Fig. 7.5.
If
c
i
is high, it may end the cycle all together. However,
c
i
could also be a way to delay how quickly Cell 3
reinitiates firing in Cell 1, thus slowing down the rate of the cyclical firing. This situation could be even
more interesting if
c
i
itself was modulated by other synapses, hormones or ionic concentrations.
