Biomedical Engineering Reference
In-Depth Information
dx
r
i
r
i
a
Mem
Figure 5.5:
Model of a single compartment.
G[
G[
E
D
2A
2A
2B
2A
2B
2B
,
P
,
P
Figure 5.6:
Impact of a radius change.
Using the function
R(a)
, we can consider the impact of coupling a patch with a small radius (
a
)toa
patch with a larger radius (
b
) as in Fig. 5.6. If we assume that all current flows from left to right and that
extracellular space is conductive (e.g.,
V
m
=
φ
i
), then at Node 1
V
m
−
V
m
V
m
−
V
m
R(a))
−
R(b))
−
I
m
=
0
(5.4)
+
+
(R(a)
(R(a)
and at Node 2
V
m
−
V
m
V
m
−
V
m
R(b))
−
R(b))
−
I
m
=
0
.
(5.5)
(R(a)
+
(R(b)
+
