Medical Image Registration: Theory, Algorithm, and Case Studies in Surgical Simulation, Chest Cancer, and Multiple Sclerosis - Biomedical Image Analysis - page 35

volume 1

Initial
estimate

Maximizing
MI using GA

Surface
Registration

volume 2

Figure 1.12: Two different volumes are fed into the system. Surface registra-
tion provides an estimate transformation between them. This result is further
enhanced by maximizing the mutual information. A Genetic Algorithms tech-
nique is used in the optimization process.

1.6.2 Multiple Sclerosis (MS) Application

Multiple sclerosis is a disease of the human central nervous system, affecting ap-
proximately 250,000 to 350,000 people in the United States alone [35]. MS results

Before Registration Before Registration

After Registration

Figure 1.13: Two different signature samples. The upper two images are from
the MR dataset; while the lower two are from the CT dataset. This figure shows
similarity of the signature images of each matched pair, although they are pro-
duced from two different datasets (CT and MR) with a different 3D volume size
(number of slices).