Systems Analysis of Arrestin Pathway Functions - Progress in Molecular Biology and Translational Science - page 452

143. Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1alpha-responsive genes involved
in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat
Genet . 2003;34:267- 273.
144. Xu L, Furlotte N, Lin Y, et al. Functional cohesion of gene sets determined by latent
semantic indexing of PubMed abstracts. PLoS One . 2011;6:e18851.
145. Chadwick W, Keselman A, Park SS, et al. Repetitive peroxide exposure reveals pleio-
tropic mitogen-activated protein kinase signaling mechanisms. J Signal Transduct .
2011;2011:636951.
146. Lima-Fernandes E, Enslen H, Camand E, et al. Distinct functional outputs of PTEN
signalling are controlled by dynamic association with b -arrestins. EMBO J .

2011;30:2557- 2568.
147. Klewe IV, Nielsen SM, Tarpø L, et al. Recruitment of beta-arrestin2 to the dopamine
D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.
Neuropharmacology . 2008;54:1215 - 1222.
148. Xiao K, Sun J, Kim J, et al. Global phosphorylation analysis of beta-arrestin-mediated
signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci
USA . 2010;107:15299- 15304.
149. Xiao K, McClatchy DB, Shukla AK, et al. Functional specialization of beta-arrestin
interactions revealed by proteomic analysis. Proc Natl Acad Sci USA . 2007;104:
12011- 12016.
150. Rose RH, Briddon SJ, Holliday ND. Bimolecular fluorescence complementation: light-
ing up seven transmembrane domain receptor signalling networks. Br J Pharmacol .
2010;159:738 - 750.
151. Zimmerman B, Beautrait A, Aguila B, et al. Differential b -arrestin-dependent confor-
mational signaling and cellular responses revealed by angiotensin analogs. Sci Signal .
2012;5:ra33.
152. Emery AC, DiRaddo JO, Miller E, et al. Ligand bias at metabotropic glutamate 1a
receptor: molecular determinants that distinguish b -arrestin from G protein-mediated
signaling. Mol Pharmacol . 2012;82:291- 301.
153. Cottingham C, Chen Y, Jiao K, Wang Q. The antidepressant desipramine is an
arrestin-biased ligand at the a (2A)-adrenergic receptor driving receptor down-
regulation in vitro and in vivo. J Biol Chem . 2011;286:36063- 36075.
154. Allen JA, Yost JM, Setola V, et al. Discovery of b -arrestin-biased dopamine D2 ligands
for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl
Acad Sci USA . 2011;108:18488- 18493.
155. Bl¨ttermann S, Peters L, Ottersbach PA, et al. A biased ligand for OXE-R uncouples
G a and G b g signaling within a heterotrimer. Nat Chem Biol . 2012;8:631 - 638.
156. Watts DJ, Strogatz SH. Collective dynamics of 'small-world' networks. Nature .

1998;393:440- 442.
157. Schadt EE, Zhang B, Zhu J. Advances in systems biology are enhancing our under-
standing of disease and moving us closer to novel disease treatments. Genetica .
2009;136:259- 269.
158. Schadt EE. Molecular networks as sensors and drivers of common human diseases.
Nature . 2009;461:218- 223.