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Visual/ b -arrestins
ARRDCs
Yeast ARTs
VPS26
Other retromer subunits
1-3,5,6,8 a
Arrestin fold
Predicted (9, b) Predicted (9, 10, b) 11,12
Polar core
3,5,20,31
n.d.
n.d.
11,12,95
Cargo binding
36,131
81
86,89
132
VPS35 97
Cargo phosphorylation
18,22,23
81
86
133
Cargo ubiquitination
134,135
81,82
89
PxY sites
None
82,130
10,85,86,130,136
Ubiquitination
41,68,69,137
10,85,87
Phosphorylation
18,60,61,65
85,87
Inositol phosphates binding
4,5,74,76,138
SNX 139
Clathrin binding
18,49,55
114,121
AP adaptor protein binding
18,66
CI-MPR 96 ;
Actin binding
40,140
110,114
Microtubule binding
118,119
ESCRT binding
28
79
88,141
Regulation by small G proteins 18,40
1 07,109,110,142
Secondary signaling platform
19,24,30-35,41,143
a Numbers correspond to references in text.
b This work.
Functions carried out by a -/ b -arrestins, absent in VPS26, but found in other subunits of the retromer, are summarized in the last column.
n.d., not determined.
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