Biology Reference
In-Depth Information
Table 14.1 Disease models with b-arrestin 1- and b-arrestin 2-deficient mice
Mouse
model
Disease
Disease model
Key phenotype
References
b
arr1
/
or
b
arr2
/
Lung fibrosis
Bleomycin-
induced lung
fibrosis
Reduced
susceptibility and
lung fibrosis
131
b
arr2
/
Reduced airway
hyperresponsiveness
Asthma
Ovalbumin
sensitization
model of asthma
55,66
b
arr2
/
Reduced
cytomegalovirus
infection
Infection
Cytomegalovirus
infection
37
b
arr2
/
More susceptible to
endotoxic shock
Sepsis
Galactosamine-
D
sensitized model
of endotoxic
shock
111
b
arr1
/
or
b
arr2
/
Sepsis
LPS injection or
cecal ligation and
puncture
Protected from
endotoxic shock
and lethality
112,135
b
arr2
/
Increased
reepithelialization
Wound healing
Skin air pouch
model of
inflammation
36
b
arr1
/
Resistant to
experimental
autoimmune
encephalomyelitis
Encephalomyelitis Experimental
autoimmune
encephalomyelitis
46
b
arr2
/
Augments stress-
induced immune
suppression
Stress
Chronic physical
restraint
62,116
b
arr1
/
Reduced cutaneous
flushing in response
to nicotinic acid
Cutaneous
flushing
Nicotinic acid-
induced
cutaneous
flushing
171
b
arr2
/
Increase in Lewis
lung cancer tumor
growth and
metastasis
Lung cancer
Heterotopic
murine Lewis
lung cancer and
tail vein metastasis
tumor model
17
b
arr2
/
More severe
arthritis in collagen-
induced arthritis
Rheumatoid
arthritis
Collagen-
induced arthritis
153
Search WWH ::
Custom Search