Biology Reference
In-Depth Information
CHAPTER FOURTEEN
-Arrestins in the Immune System
b
Dianhua Jiang, Ting Xie, Jiurong Liang, Paul W. Noble
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University
School of Medicine, Durham, North Carolina, USA
Contents
1.
Introduction
360
2.
b-Arrestins in Innate Immunity
361
2.1
b-Arrestins and macrophages
361
2.2
b-Arrestins and polymorphonuclear leukocytes
362
2.3
b-Arrestins and natural killer cells
363
2.4
b-Arrestins and mast cells
363
2.5
b-Arrestins and complement
363
3.
b-Arrestins in Adaptive Immunity
364
3.1
b-Arrestins and lymphocytes
364
3.2 T-cell activation
365
3.3 Migration and chemotaxis
365
3.4 Lymphocyte survival and apoptosis
365
3.5 TH1, TH2, and TH17 cells
366
4.
b-Arrestins and Structural Cells
367
5.
b-Arrestins Regulate Immune Signaling Pathways
367
5.1
b-Arrestins and chemokine receptors
367
5.2
b-Arrestins and other GPCRs in inflammation
369
5.3
b-Arrestins and TLR signaling
371
5.4 Other non-GPCR signaling pathways
373
6. Role of b-Arrestins in Human Diseases
374
6.1 Pathogen recognition and clearance
374
6.2 Fibrosis
377
6.3 Arthritis
379
6.4 Multiple sclerosis
380
6.5 Encephalomyelitis
381
6.6 Acute rejection in organ transplant
381
6.7 Asthma
381
6.8 Cystic fibrosis
382
6.9 Cardioprotection
382
7.
b-Arrestins in Therapeutic Development for Inflammatory Diseases
383
References
384
Search WWH ::
Custom Search