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Type 1
Type 1
b 2 AR ligands:
b 2 AR ligands:
AT 1 R ligands (sartans):
AT 1 R ligands (sartans):
HN
N
R 1
N
N
HO
H
H
Tetrazol-biphenyl-
methyl derivatives
N
CH 3
Isoproterenol
CH 3
HO
OH
OH
N
HN
N
N
OH
CCH 2 NHCH 3
H
Cl
N
HO
Losartan
Epinephrine
HO
H
O
HN
O
OH
N
N
N
HN
N
Formoterol
N
CH 3
HO
OCH 3
Irbesartan
Type 2
Type 2
b
b
2 AR ligands:
2 AR ligands:
O
OH
HN
N
N
N
N
Candesartan
OH
N
N
O
Carazolol
O
CH 3
CH 3
CH 2
O
H
CH 3
CH 3
HN
Alprenolol
N
N
N
N
O
H
O
OH
Valsartan
Type 3
Type 3
b 2 AR ligands:
b 2 AR ligands:
OH
H
HO
CH 3
CH 3
Isoetharine
HO
CH 3
OH
CH
OCH 2
CH 2 NHCH 2 CH 2 O
Carvedilol
CH 3 O
N
H
N
NH
H 3 C
CH 3
Bucindolol (?)
O
N
H
OH
Type 4
Type 4
b 2 AR ligands:
b 2 AR ligands:
HO
H
H
HO
OH
Nadolol (?)
O
NH
Figure 12.1 Chemical structures of the b 2 AR (left column) and AT 1 R (right column)
ligands discussed in Section 6 . Left column: light pink indicates the aromatic “head
group”; light blue, the ethanolamine “tail”; and olive green, the two-atom “linker.” Notice
the absence of this two-atom linker from ligands that have agonistic activity at the b 2 AR.
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