b-Arrestins in the Central Nervous System - Progress in Molecular Biology and Translational Science - page 264

A B C

AT 1A , β 2 AR, D1R

D2R DOR

Ligand

Ligand Ligand

PP2A

β -Arr2

A
K
T
S473 T308
Active form

S9/S21

P

GSK3

P P

β -Arr1

β -Arr2

Inactive form

Raf

Erk1/2

Translocation
to nucleus MEK

β -Arr2

Erk1/2

A
K
T

PP2A

p300

Active form

S473

GSK3
Active form

H4

P

CREB

Inactive form

Transcription

D E

5HT 4 5HT 2A

Ligand

5HT

β -Arr2

β -Arr1

GRK5

A

P

K
T

S412

SRC

P

Erk1/2

Behavioral response
(head twitch)

Inactive form

Figure 11.2 Illustration of some arrestin-dependent signaling complexes in the central
nervous system. (A) The type 1 of dopamine receptor (D1R), AT1A, b2AR, as well as
potentially 5HT receptors, regulates formation of a protein complex composed of
b-arrestin 2/ERK/Raf, and putatively MEK, leading to ERK1/2 activation and regulation
(Continued)