Arrestins as Regulators of Kinases and Phosphatases - Progress in Molecular Biology and Translational Science - page 122

Effector Arrestin Reported functions References

Tyrosine protein kinases
Src family tyrosine
kinases
c-Src, c-Yes, c-Hck,
c-Fgr, c-Fyn

Arrestin1
Arrestin2
Arrestin3

ERK1/2 activation
Dynamin 1 phosphorylation
Exocytosis/granule release
Phosphorylation/destabilization of
GRK2
FAK phosphorylation
EGF receptor transactivation
Phosphorylation of b 2-adaptin
subunit of AP-2 complex

6,11
59
12
60

61
62
48

SER/THR protein kinases
c-Raf1-MEK1/
2-ERK1/2

Arrestin2
Arrestin3

Activation of cytosolic ERK1/2
p90RSK phosphorylation
Actin cytoskeletal reorganization/
chemotaxis
ERK1/2-dependent transcription
Mnk1/eIF4E phosphorylation/
protein translation

14,15
63
49

64
35

Inhibitio n of cytosolic JNK3
Activation of cytosolic JNK3

ASK1-MKK4-JNK3 Arrestin1
Arrestin2
Arrestin3

36
13

ASK1-MKK3-p38
MAPK

Arrestin2
Arrestin3

Activation of p38 MAPK
Inhibition of p38 MAPK

65,66
67

I k B a -I k B kinase a / b Arrestin2
Arrestin3

Attenuation of NF- k B signaling 19,55,56

Casein kinase 2 Arrestin3 Activation of CK2 58

Protein phosphatases

PP2A-Akt-GSK3 b Arrestin3 Activation of Akt

Inactivation of Akt-GSK3 b /
Activation of b -catenin signaling

58,68
23

Cofilin, chronophin,
LIM kinase

Arrestin3 Actin cytoskeletal reorganization/
chemotaxis

21

SHP-1, SHP-2 Arrestin3 Inhibition of NK cell cytotoxicity 69

Lipid kinases

Diacylglycerol kinase Arrestin2
Arrestin3

Attenuation of PKC signaling 18

Phosphatidylinositol
3-kinase

Arrestin2 Inhibition of PI3K 70

PI 4-phosphate
5-kinase I a

Arrestin2
Arrestin3

Control of GPCR internalization 71