Biomedical Engineering Reference
In-Depth Information
Figure 7.3 Bone apposition at the interface of a PEEK
interbody spinal fusion device in an ovine model
showing direct bone contact with the PEEK interbody
device (trichrome stain, original magnification
Figure 7.5 Histology image demonstrating fibrous
tissues (pink) and cartilage (purple) at the interface of
the far lateral aspect of a PEEK interbody spinal fusion
device in an ovine model (trichrome stain, mm scale in
field).
100
).
¼
the flat surfaces of the PEEK device compared with
a fused implant.Motion of the spinal level can result in
motion at the PEEK device interface, which can
disrupt the vascularity at the device interface. This
may result in fibrous tissues and cartilage at the PEEK
device interface, as seen in Figs 7.4 and 7.5 . If pseu-
darthrosis occurs, relative motion between bone and
the PEEK implant can generate PEEK particulate
debris in periprosthetic tissues. Figure 7.6 shows
tissues adjacent to a PEEK interbody spinal fusion
device in an ovine model demonstrating a mono-
nuclear response (macrophages predominate) with
intracellular PEEK particulate debris in periprosthetic
fibrous connective tissues. PEEK particulate debris
can be generated if the interbody device fails to fuse or
Figure 7.6 Tissues adjacent to a PEEK interbody
spinal fusion device in an ovine model showing a mono-
nuclear response (macrophages predominate) with
intracellular PEEK particulate debris in fibrous connec-
tive tissues adjacent to de novo bone. PEEK particulate
debris can be generated if the interbody device fails to
fuse or if instability exists (WrighteGiemsa stain, orig-
inal magnification
Figure 7.4 Histologic nonfusion within the through-
growth region of a PEEK interbody spinal fusion device
in an ovine model. Macroscopically, less bone contact
is observed along the flat surfaces of the PEEK device
compared with a fused implant (trichrome stain, mm
scale in field).
200
).
¼
Search WWH ::




Custom Search