Biomedical Engineering Reference
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(b)
(a)
(c)
Figure 12.4 Implantation sites for sample comparison between solid and porous PEEK.
Porous PEEK implanted into cancellous bone had
good apposition with the bone
by an increase in the implant e bone contact in
cancellous and cortical sites. This osseoconductivity
at the implant e bone interface also resulted in
increased mechanical fixation in the cortical sites. All
PEEK and porous PEEK implants were well tolerated
by the body d which demonstrated that the porous
process and alternative porous configuration had no
adverse effect. Although a porous PEEK material
would not possess any different chemical properties
over solid PEEK to facilitate an osseointegrative
chemical bond, it may confer some topographical
influences. In previous studies, it was observed that
surface finish (such as injection molded vs. rougher
and showed
implant e bone integration ( Fig. 12.9 ).
12.5.8 Discussion
From these preliminary studies into a porous
PEEK fabricated using leaching of a porogen
compound, it appeared that creating a resultant 50%
porous PEEK material can support differentiated
cells and mineralization in vitro. More importantly,
when tests were transferred to in vivo, there was
evidence of some osteoconductivity, as demonstrated
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