Biomedical Engineering Reference
In-Depth Information
the observed reduction in filament density toward the back of the lamellipodia
and the realignment of filaments parallel to the direction of cell migration that
occur at the back of the lamellipodia.
Overall, it can said that intracellular mechanical factors couple with biochemical
factors in the regulation of actin filament dynamics, and in doing so, contributes to
the regulation of cell motility.
References
Adachi T, Okeyo KO, Shitagawa Y, Hojo M (2009) Strain field in actin filament network in lamel-
lipodia of migrating cells: implication for network reorganization. J Biomech 42(3):297-302.
Burnette DT, Manley S, Sengupta P, Sougrat R, Davidson MW, Kachar B, Lippincott-Schwartz J
(2011) A role for actin arcs in the leading-edge advance of migrating cells. Nat Cell Biol
13(4):371-381. doi:
10.1038/ncb2205
Costa KD, Hucker WJ, Yin FCP (2002) Buckling of actin stress fibers: a new wrinkle in the cyto-
skeletal tapestry. Cell Motil Cytoskeleton 52(4):266-274. doi:
10.1002/cm.10056
Danuser G, Waterman-Storer CM (2006) Quantitative fluorescent speckle microscopy of cytoskel-
eton dynamics. Annu Rev Biophys Biomol Struct 35:361-387. doi:
10.1146/annurev.
De La Cruz EM, Pollard TD (1994) Transient kinetic-analysis of rhodamine phalloidin binding to
actin-filaments. Biochemistry 33(48):14387-14392
Hayakawa K, Tatsumi H, Sokabe M (2003) ADF/cofilin is involved in stress fiber disassembly by
periodic stretching. Biophysics 43(S1):S162
Higashida C, Miyoshi T, Fujita A, OcegueraYanez F, Monypenny J, Andou Y, Narumiya S,
Watanabe N (2004) Actin polymerization-driven molecular movement of mDia1 in living cells.
Science 303(5666):2007-2010
Hu K, Ji L, Applegate KT, Danuser G, Waterman-Storer CM (2007) Differential transmission of
actin motion within focal adhesions. Science 315(5808):111-115
Huang ZJ, Haugland RP, You WM, Haugland RP (1992) Phallotoxin and actin binding assay by
fluorescence enhancement. Anal Biochem 200(1):199-204
Jurado C, Haserick JR, Lee J (2005) Slipping or gripping? Fluorescent speckle microscopy in fish
keratocytes reveals two different mechanisms for generating a retrograde flow of actin. Mol
Biol Cell 16(2):507-518. E04-10-0860 [pii]
Kovar DR, Harris ES, Mahaffy R, Higgs HN, Pollard TD (2006) Control of the assembly of ATP-
and ADP-actin by formins and profilin. Cell 124(2):423-435
Laurent VM, Kasas S, Yersin A, Schaffer TE, Catsicas S, Dietler G, Verkhovsky AB, Meister JJ
(2005) Gradient of rigidity in the lamellipodia of migrating cells revealed by atomic force
microscopy. Biophys J 89(1):667-675. doi:
10.1529/biophysj.104.052316
Lee J, Ishihara A, Theriot JA, Jacobson K (1993) Principles of locomotion for simple-shaped cells.
Nature 362(6416):167-171
Mahaffy RE, Pollard TD (2008) Influence of phalloidin on the formation of actin filament branches
by Arp2/3 complex. Biochemistry US 47(24):6460-6467
McCullough BR, Blanchoin L, Martiel J-L, De La Cruz EM (2008) Cofilin increases the bending
flexibility of actin filaments: implications for severing and cell mechanics. J Mol Biol
381(3):550-558
Miyoshi T, Tsuji T, Higashida C, Hertzog M, Fujita A, Narumiya S, Scita G, Watanabe N (2006)
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin
network: evidence of frequent filament severing. J Cell Biol 175(6):947-955
