Biomedical Engineering Reference
In-Depth Information
a
b
t = t
lp
(
t
)
t = t +
∆
t
lp
(
t +
∆
t
)
Center
region
x
o
y
F-ac
tin
Lamellipodia
Qdot
phalloidin
Contractile forces generated
by SFs
Qdot-phalloidin
on filament
Myosin
c
Forces generated by contraction
of actomyosin system
Actin
filament
l
(
t+
∆
t
)
l
(
t
)
Displacement
l
(
t +
∆
t
) -
l
(
t
)
l
(
t
)
∆ε
p
∆
t
(= 4 s)
Fig. 4.2
Schematics of continuum-based strain analysis and network deformation. (
a
) The coor-
dinate system used for the analysis (Adachi et al.
2009
). A representative region taken at the center
of lamellipodia (
gray shaded area
) is analyzed. (
b
) Time dependent deformation of a representa-
tive unit meshwork. (
c
) Schematic illustration of filament alignment and network deformation due
to actomyosin contraction (Adapted with permission from Elsevier Ltd.: [Journal of Biomechanics],
copyright (2008))
