Biomedical Engineering Reference
In-Depth Information
process. We have also discussed the spatial distribution of the actin cytoskeleton and
mentioned that it is denser at the leading edge where polymerization occurs.
Furthermore, we have seen that fi lament alignment varies from the leading edge
toward the inner region of the lamellipodia, where they tend to align parallel to the
leading edge. At the back of the lamellipodia, bundling of several actin fi laments by
crosslinking factors results in the formation of actin-stress fi bers that are important
in the generation contractile forces. In the next chapter we take a closer look at the
mechanical factors in play during cell migration and how these couple with bio-
chemical factors in the regulation of cell motility.
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