Biology Reference
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74. Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, et al. Detection of
dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice.
Gastroenterology 2002; 122 :406-14.
75. Bremer C, Tung CH, Bogdanov Jr. A, Weissleder R. Imaging of differential protease
expression in breast cancers for detection of aggressive tumor phenotypes. Radiology
2002; 222 :814-8.
76. Wunderbaldinger P, Turetschek K, Bremer C. Near-infrared fluorescence imaging of
lymph nodes using a new enzyme sensing activatable macromolecular optical probe.
Eur Radiol 2003; 13 :2206-11.
77. Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, et al. In
vivo imaging of HIV protease activity in amplicon vector-transduced gliomas. Cancer
Res 2004; 64 :273-8.
78. Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U. In vivo imaging
of protease activity in arthritis: a novel approach for monitoring treatment response.
Arthritis Rheum 2004; 50 :2459-65.
79. Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, et al. A novel
method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neo-
plasia 2004;
:95-105.
80. Lai WF, Chang CH, Tang Y, Bronson R, Tung CH. Early diagnosis of osteoarthritis
using cathepsin B sensitive near-infrared fluorescent probes. Osteoarthritis Cartilage
2004; 12 :239-44.
81. Lamfers ML, Gianni D, Tung CH, Idema S, Schagen FH, Carette JE, et al. Tissue in-
hibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix
metalloproteinase activity in vivo without affecting antitumor efficacy in malignant gli-
oma. Cancer Res 2005; 65 :9398-405.
82. Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL. Near-infrared fluo-
rescent imaging of matrix metalloproteinase activity after myocardial infarction. Circu-
lation 2005; 111 :1800-5.
83. Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, et al. Use
of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc
Natl Acad Sci USA 2005; 102 :14404-9.
84. Hsiao JK, Law B, Weissleder R, Tung CH. In-vivo imaging of tumor associated
urokinase-type plasminogen activator activity. J Biomed Opt 2006; 11 :34013.
85. Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, et al. Inflam-
mation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in
vivo. Circulation 2006; 114 :55-62.
86. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, et al.
Dual channel optical tomographic imaging of leukocyte recruitment and protease ac-
tivity in the healing myocardial infarct. Circ Res 2007; 100 :1218-25.
87. Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, et al. Optical visual-
ization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluo-
rescence sensor. Circulation 2007; 115 :2292-8.
88. Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U. Co-
lonic adenocarcinomas: near-infrared microcatheter imaging of smart probes for early
detection—study in mice. Radiology 2007;
6
:232-8.
89. Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, et al. A target cell-
specific activatable fluorescence probe for in vivo molecular imaging of cancer based on
a self-quenched avidin-rhodamine conjugate. Cancer Res 2007; 67 :2791-9.
90. Hama Y, Urano Y, Koyama Y, Gunn AJ, Choyke PL, Kobayashi H. A self-quenched
galactosamine-serum albumin-rhodamineX conjugate: a “smart” fluorescent molecular
imaging probe synthesized with clinically applicable material for detecting peritoneal
ovarian cancer metastases. Clin Cancer Res 2007; 13 :6335-43.
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