Fluorescent Protein-Based Biosensors and Their Clinical Applications - Progress in Molecular Biology and Translational Science - page 345

62. Berg J, Hung YP, Yellen G. A genetically encoded fluorescent reporter of ATP:ADP
ratio. Nat Methods 2009;6:161-6.
63. Johnsson N, Varshavsky A. Split ubiquitin as a sensor of protein interactions in vivo.
Proc Natl Acad Sci USA 1994;91:10340-4.
64. Pelletier JP, Mineau F, Fernandes JC, Duval N, Martel-Pelletier J. Diacerhein and rhein
reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activ-
ity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
J Rheumatol 1998;25:2417-24.
65. Rossi F, Charlton CA, Blau HM. Monitoring protein-protein interactions in intact
eukaryotic cells by beta-galactosidase complementation. Proc Natl Acad Sci USA
1997;94:8405-10.
66. Hu C, Chinenov Y, Kerppola T. Visualization of interactions among bZIP and Rel
family proteins in living cells using bimolecular fluorescence complementation. Mol
Cell 2002;9:789-98.
67. Wehrman T, Kleaveland B, Her J-H, Balint RF, Blau HM. Protein-protein interac-
tions monitored in mammalian cells via complementation of beta-lactamase enzyme
fragments. Proc Natl Acad Sci USA 2002;99:3469-74.
68. Galarneau A, Primeau M, Trudeau L-E, Michnick SW. Beta-lactamase protein frag-
ment complementation assays as in vivo and in vitro sensors of protein protein inter-
actions. Nat Biotechnol 2002;20:619-22.
69. Spotts JM, Dolmetsch RE, Greenberg ME. Time-lapse imaging of a dynamic
phosphorylation-dependent protein-protein interaction in mammalian cells. Proc Natl
Acad Sci USA 2002;99:15142-7.
70. Paulmurugan R, Umezawa Y, Gambhir SS. Noninvasive imaging of protein-protein
interactions in living subjects by using reporter protein complementation and recon-
stitution strategies. Proc Natl Acad Sci USA 2002;99:15608-13.
71. Remy I, Michnick SW. A highly sensitive protein-protein interaction assay based on
Gaussia luciferase. Nat Methods 2006;3:977-9.
72. Kerppola T. Visualization of molecular interactions by fluorescence complementation.
Nat Rev Mol Cell Biol 2006;7:449-56.
73. Kerppola TK. Bimolecular fluorescence complementation (BiFC) analysis as a probe of
protein interactions in living cells. Annu Rev Biophys 2008;37:465-87.
74. Ghosh I, Hamilton AD, Regan L. Antiparallel Leucine Zipper-Directed Protein
Reassembly: Application to the Green Fluorescent Protein. J Am Chem Soc

2000;122:5658-9.
75. Bracha-Drori K, Shichrur K, Katz A, Oliva M, Angelovici R, Yalovsky S, et al.
Detection of protein-protein interactions in plants using bimolecular fluorescence
complementation. Plant J. 2004;40:419-27.
76. Chen B, Liu Q, Ge Q, Xie J, Wang Z-W. UNC-1 regulates gap junctions important to
locomotion in C. elegans. Curr Biol 2007;17:1334-9.
77. Fujioka Y, Utsumi M, Ohba Y, Watanabe Y. Location of a possible miRNA processing
site in SmD3/SmB nuclear bodies in Arabidopsis. Plant Cell Physiol 2007;48:1243-53.
78. Hu C-D, Kerppola TK. Simultaneous visualization of multiple protein interactions in
living cells using multicolor fluorescence complementation analysis. Nat Biotechnol
2003;

:539-45.
79. Grinberg AV, Hu C-D, Kerppola TK. Visualization of Myc/Max/Mad family dimers
and the competition for dimerization in living cells. Mol Cell Biol 2004;24:4294-308.
80. Robida AM, Kerppola TK. Bimolecular fluorescence complementation analysis of in-
ducible protein interactions: effects of factors affecting protein folding on fluorescent
protein fragment association. J Mol Biol 2009;394:391-409.
81. Tsutsumi K, Fujioka Y, Tsuda M, Kawaguchi H, Ohba Y. Visualization of Ras-PI3K
interaction in the endosome using BiFC. Cell Signal 2009;21:1672-9.

21