Biology Reference
In-Depth Information
CHAPTER ONE
The Chemistry of Small-Molecule
Fluorogenic Probes
Jonathan B. Grimm, Laurel M. Heckman, Luke D. Lavis
Janelia Farm Research Campus, The Howard Hughes Medical Institute, Ashburn, Virginia, USA
Contents
1.
Introduction
2
2. Fluorescence and Fluorophores
3
3. Modes of Fluorescence Modulation
3
4. Coumarins
6
4.1 Overview
6
4.2 Fluorogenic enzyme substrates
7
4.3 Photoactivatable probes
8
4.4 Indicators
9
5. BODIPY Dyes
9
5.1 Overview
9
5.2 Enzyme substrates
10
5.3 Indicators
10
6. Fluoresceins
11
6.1 Overview
11
6.2 Enzyme substrates
12
6.3 Photoactivatable probes
13
6.4 Indicators
14
7. Rhodamines
14
7.1 Overview
14
7.2 Enzyme substrates
16
7.3 Photoactivatable probes
16
7.4 Indicators
17
8. Phenoxazine Dyes
18
8.1 Overview
18
8.2 Enzyme substrates
19
8.3 Photoactivatable probes
20
8.4 Indicators
20
9. Acridinones
21
9.1 Overview
21
9.2 Fluorogenic enzyme substrates and photoactivatable probes
21
 
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