Biomedical Engineering Reference
In-Depth Information
FIGURE 3.1
The three FP component types.
3.1.2 FPs Classified by the Function of Each
Component
(Ab) scFv (binding), or Ab Fc (effector) function. FPs
could be classified in any number of ways; however, this
approach was chosen since it allows key differences to be
drawn out. Identification codes relating to the FP compo-
nent combinations shown in Figure 3.2 are referenced
throughout this chapter.
Targeting moieties have simply been split into those
based on antibody-type structures (Ab), and those that use
other approaches to bind targets such as receptor domains or
ligands (non-Ab). Ab structures are defined as full anti-
bodies, or scFv-type antigen-binding portions. Different
types of half-life partner identified have been left grouped
but are discussed in detail in this chapter.
We identified FPs that are marketed or in development
using Cl inica lTri als . gov, c o mpany w ebs ite s, PubMe d , and
internet search engines. A total of 43 FPs are in Phase II
development or more advanced. Only those in the Phase II
portion of a Phase I/II trial have been considered, while any
stated as discontinued have been excluded.
Figure 3.2 shows these FP products classified by the
role or function of their activity, targeting, or half-life
components. Activity moieties are shown on the x-axis,
classified according to whether the function is imparted
by a receptor, enzyme, toxin, ligand, antigen, antibody
FIGURE 3.2
Classification of FPs in Phase II or above, according to component function. Note:
The number in the bottom left corner of each segment indicates the number of products, whereas that
on the right is the cell identification code.
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