Biomedical Engineering Reference
In-Depth Information
proteins, by creating second-generation proteins with
improved characteristics. This will on one hand enable
life-cycle management for some companies with established
drugs, but on the other hand enable new market entrants to
place novel variants of a proven product.
15. Duttaroy A, Kanakaraj P, Osborn BL, Schneider H, Pickeral
OK, Chen C, et al. (2005) Development of a long-acting insulin
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18. Zhao HL, Xue C, Du JL, Ren M, Xia S, Liu ZM. (2012)
Balancing the pharmacokinetics and pharmacodynamics of
interferon- a 2b and human serum albumin fusion protein by
proteolytic or reductive cleavage increases its in vivo thera-
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19. Zhan J, Chen Y, Yuan H-Y, Li H, Lu H. (2012) Fusion of HSA
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of the affinity of monoclonal antibodies and Fc-fusion proteins
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