Biomedical Engineering Reference
In-Depth Information
clinical applications of bioceramic and composite scaffolds. The effect of dissolution products of bio-
active glasses on angiogenesis demonstrated recently both
in vivo
and
in vitro
offers another alter-
native to the development of 3-D scaffolds with improved vascularization potential [55]. As such,
prevascularization by using VGF is a highly recommended strategy in the design of synthetic tissue
scaffolds. Other relevant issues include the optimization of surface functionalization and surface
topography of scaffolds, as well as the development of advanced scaffolds with the capability to
release other biomolecules, such as antibiotics, vitamins, or BGF during their degradation
in vivo
.
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