Biomedical Engineering Reference
In-Depth Information
materials and functional systems. The selection of appropriate nanostructures as supports for
hybridization is surely important. In this chapter, several powerful candidates of nanostructures are
presented. The lipid assemblies would be one of the most important supports for biohybrid nanoma-
terials. Amphiphilic molecules such as lipids and surfactants usually provide micelles or vesicles,
but many kinds of superbilayer structures have been reported [124-132]. These superstructures are
potentially fabricated into various nanostructures, upon wise design of the component materials.
Support fi lms composed of polyelectrolytes prepared by LbL assembling technique have higher
permeability of substances for enzymatic reaction than a lipid-based fi lm. Therefore, systems for
functional relation along the normal direction of the LbL fi lms should be pursued. Some practical
applications require mechanical stability of biohybrid nanomaterials, which were accomplished by
hybridization of biomaterials with inorganic mesoporous supports. Due to their huge surface area,
the mesoporous material also provides facile contact with external chemical substances to immo-
bilized biomaterials.
The approaches presented in this chapter involve supramolecular chemistry and molecular
assembly technology. In such supramolecular approaches, free design of biohybrids can be pro-
vided on the basis of huge freedom in the selection of components, control of support structures,
interfacing with artifi cial devices, and combination of these systems. Many kinds of nanosized
functional systems can be fl exibly imagined, designed, and constructed upon the fl exible nature of
supramolecular chemistry with the aid of our fl exible thinking.
ACKNOWLEDGMENT
The research described in this chapter was partially supported by Ground-Based Research Program
for space utilization promoted by Japan Space Forum.
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