Biomedical Engineering Reference
In-Depth Information
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FIGURE 11.54
Images of electrospraying patterns for Jurkat cell suspension. (Reprinted from Jayasinghe,
S.N., Qureshi, A.N., and Eagles, P.A.M.,
Small
, 2, 216, 2006. © John Wiley & Sons Inc. With permission.)
aerosolize living cells using electrospraying without harming cell integrity. This demonstrates
that the technique is a novel method for atomizing living cells. The potential of the preliminary
fi ndings has wide implications for the aerosolization and deposition of a range of living cellular
materials.
Li et al. investigated the capability of electrospraying for aerosolizing drug particles [112].
Aspirin is one of the most popular drugs in the world and has been selected as a model compound
in the study because of its functions in the relief of headaches, muscle, and joint aches. A cone-jet
spraying mode was used to generate monodispersed distribution of droplet relics, leading to the
formation of particulate aspirin crystals in this study. A stable cone-jet mode of aerosolization was
determined by the surface tension, the density, the electrical conductivity, the viscosity, and the
relative permittivity of the solution. The solutions were prepared by dissolving the aspirin powder
into an ethanol solvent with a continuous stirring at 37°C. The concentration of aspirin powder com-
pletely soluble in ethanol was found to be 200 g/L. The equipment used for aerosolizing the aspirin
