Biomedical Engineering Reference
In-Depth Information
(a)
9
No DNA
0.5 mg/mL DNA
1.0 mg/mL DNA
8
7
6
5
4
3
0.2
0.4
0.6
0.8
1
1.2
1.4
Liquid flow rate (
µ
L/s)
(b)
100
80
60
40
20
0
0.1
1
10
100
Droplet diameter (
µ
m)
FIGURE 11.51 Electrosprayed aerosol properties are as follows: (a) aerosol size with liquid delivery rate and
(b) production of monodispersed DNA aerosols. (Reprinted from Davies, L.A. et al., Pharmaceut. Res. , 22,
1294, 2005. © Springer Science and Business Media. With permission.)
Solution was sonicated for 3 min to remove any bubbles that might cause spray instabilities before
being transferred into the reservoir syringe.
The results showed that the highest fl ow rate at which a stable electrospraying was sustained was
0.38 µL/min, which corresponded to a production rate of about 0.23 mg/h. At a l ow rate of 2.2 µL/
min, it was still possible to stabilize the conical meniscus but was diffi cult to achieve monodispersed
spraying mode. The higher feed rates resulted in unstable behavior of the conical meniscus. Figure
11.53 shows SEM images of particles produced using a fl ow rate of 0.17 mL/min. The microstructure
revealed that the electrosprayed protein particles were typically shaped as doughnuts, and some
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