Biomedical Engineering Reference
In-Depth Information
IBU
loading
Sustained
release
Washing
pH=2.0
PAH / PSS coating
Controlled
release
FIGURE 9.3
Schematic illustration of two drug delivery systems that provide different controlled-release
patterns. (Reprinted from Zhu, Y.F. et al.,
Angew. Chem. Int. Ed.
, 44, 5083, 2005.)
b
a
200 nm
50 nm
PAH/PSS multilayered mesoporous
shell
c
d
hollow core
50 nm
50
nm
FIGURE 9.4
TEM micrographs: (a and b) hollow mesoporous silica spheres, (c) ibuprofen-hollow meso-
porous silica spheres, and (d) ibuprofen-hollow mesoporous silica spheres with polyelectrolyte multilayers.
(Reprinted from Zhu, Y.F. et al.,
Angew. Chem. Int. Ed.
, 44, 5083, 2005.)