Biomedical Engineering Reference
In-Depth Information
OH
Drug
Drug
=
O
CdS
S
Drug
Drug
Drug
Drug
CdS
Drug
Drug
Drug
NH
3
Drug
Drug
Drug
=
Drug
Drug
S
S
Drug
CdS
Drug
Mesoporous silica nanosphere
Drug
CdS
Drug
Amidation
CdS nanoparticle
CdS
S
Disulfide linker
Drug
Drug
O
Drug
HN
CdS
CdS
CdS
Drug
Drug
=
S
Drug
MSN
S
Drug
CdS
Drug
CdS
Drug
Drug
Mesoporous silica monosphere
Si
O
O
O
MSN
Disulfide
cleavage
SH
Dithiothreitol
(DTT)
OH
HS
OH
SH
Drug
Drug
Drug
CdS
CdS
CdS
Drug
Drug
SH
SH
CdS
Drug
SH
Drug
Mesoporous silica monosphere
Drug
Drug
Drug
FIGURE 8.7
Schematic representation of the drug/neurotransmitter delivery system based on the CdS
nanoparticle-capped MCM-41 type mesoporous silica nanospheres. The controlled-release mechanism of the
system is based on chemical reduction of the disulfi de linkage between the CdS caps and the MSN hosts.
(Reprinted from Lai, C.Y. et al.,
J. Am. Chem. Soc.
, 125, 4451, 2003.)
