Biomedical Engineering Reference
In-Depth Information
A. Membrane
B. Matrix
C. Erodible matrix
Insulin
Medium
Glucose-sensitive hydrogel
Insulin-loaded hydrogel
Gasket, supporter
Dialysis membrane
Ultrafiltration membrane (0.1
ยต
m)
(a)
30
Pi(AG-
co
-SPAK)
Pi(AG-
co
-VP)
Pi(AG-
co
-AM)
25
20
15
10
5
0
0
10
20
30
40
50
60
70
1
0.75
0.5
0.25
0
0
10
20
30
Time (h)
40
50
60
70
(b)
FIGURE 8.4
(a) Schematic representation of modulated insulin-delivery systems using phase-reversible
glucose-sensitive hydrogels. Arrows indicate the direction of insulin release from the systems. (b) Cumula-
tive amount of the released insulin and insulin release rate measured as a function of time through glucose-
sensitive hydrogel membranes under stepwise changes of the glucose concentration using the glucose-sensitive
matrix systems. (Reprinted from Kim, J.J. and Park, K.,
J. Contr. Release
, 77, 39, 2001.)
