Nanoparticles in Cancer Drug Delivery Systems - Biomaterials Fabrication and Processing - page 143

6 Nanoparticles in Cancer

Drug Delivery Systems

So Yeon Kim and Young Moo Lee

CONTENTS

6.1 Introduction........................................................................................................................... 144
6.2 Chemotherapy ....................................................................................................................... 144
6.2.1 Tumor Tissues............................................................................................................ 144
6.2.2 Problems of Chemotherapy ....................................................................................... 145
6.3 Nanoparticles in Cancer Therapy ......................................................................................... 145
6.3.1 Particulate Drug Carriers .......................................................................................... 145
6.3.2 Liposomes.................................................................................................................. 147
6.3.3 Polymeric Nanoparticles ........................................................................................... 148
6.3.4 Other Nanostructures ................................................................................................ 150
6.3.4.1 Dendrimers.................................................................................................. 150
6.3.4.2 Magnetic Nanoparticles .............................................................................. 150
6.3.4.3 Ceramic Nanoparticles................................................................................ 151
6.3.4.4 Metal Nanoparticles .................................................................................... 151
6.3.4.5 Albumin Nanoparticles ............................................................................... 152
6.4 In Vivo Biodistribution.......................................................................................................... 152
6.4.1 Biodistribution of Particulate Drug Carriers............................................................. 152
6.4.2 Physicochemical Factors Infl uencing Biodistribution
of Particulate Drug Carriers...................................................................................... 153
6.4.2.1 Particle Size................................................................................................. 153
6.4.2.2 Surface Hydrophobicity .............................................................................. 153
6.4.2.3 Surface Charge............................................................................................ 154
6.4.3 Design of Long-Circulating Nanoparticles:
PEO-Modifi ed Nanoparticles .................................................................................... 154
6.5 Targeted Drug Delivery for Chemotherapy .......................................................................... 156
6.5.1 Drug Targeting .......................................................................................................... 156
6.5.2 Passive Targeting ....................................................................................................... 156
6.5.3 Active Targeting ........................................................................................................ 156
6.5.3.1 Tumor-Specifi c Targeting............................................................................ 157
6.5.3.2 Inhibition of Angiogenesis .......................................................................... 162
6.5.3.3 Vascular Targeting ...................................................................................... 162
6.5.4 In Vivo Studies with Nanoparticulates
for Targeted Chemotherapy ....................................................................................... 163
6.6 Conclusions ........................................................................................................................... 164
References ...................................................................................................................................... 164

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