Biomedical Engineering Reference
In-Depth Information
Fig. 9.4
Magnetic nanoparticle-coated stent
Drugs Encapsulated in Biodegradable Nanoparticles
Local delivery of antiproliferative drugs encapsulated in biodegradable nanoparti-
cles has shown promise as an experimental strategy for preventing restenosis devel-
opment. A novel PDGFR b-specific tyrphostin, AGL-2043 (Calbiochem), was
formulated in polylactide-based nanoparticles and was administered intraluminally
to the wall of balloon-injured rat carotid and stented pig coronary arteries (Banai
et al.
2005
). The antiproliferative effect of nanoencapsulated tyrphostin was found
to be considerably higher than that of surface-adsorbed drug. In the pig model,
intramural delivery of AGL-2043 resulted in reduced in-stent neointima formation
in the coronary arteries as compared to control, despite similar degrees of wall
injury. The results of this study suggest that locally delivered tyrphostin AGL-2043
formulated in biodegradable nanoparticles may be applicable for antirestenotic
therapy independent of stent design or type of injury.
Magnetic Nanoparticle-Coated DES
Biophan Technologies' (Fig.
9.4
) drug delivery technology, based on tuning mag-
netic nanoparticles (MNPs) to resonate at a specific frequency, led to their use for
selective control of drug release. This technology which can be used for reloading
drug-eluting coatings for surface elution on demand is active in contrast to the
Search WWH ::
Custom Search