Molecular Diagnosis of Cardiovascular Disorders - Applications of Biotechnology in Cardiovascular Therapeutics - page 143

Table 5.1 A selection of companies involved in molecular diagnostics for cardiovascular diseases

Test/company Method/application Status/comments

Biochip technology to
simultaneously measure four
cardiac biomarkers of patients
with chest pain and suspected
CAD with results in <30 min

Marketed for research
and clinical
laboratories

Cardiac Array Evidence
Investigator ™ /Randox
Laboratories

CardiaRisk/Myriad
Genetic Laboratories

Genetic analysis of the AGT gene
to identify analyzing genetic
factors that influence a patient's
hypertension and responsiveness
to various interventions to
individualize therapy

Marketed

Corus CAD/CardioDX Blood text for measuring

expression of 23 genes to
identify patients at risk
for CAD

Marketed

Elecsys ® proBNP/Roche
Diagnostics

Automated immunoassay
for diagnosis of CHF by detecting
the level of the NT-proBNP

Approved by the FDA

FAMILION ™ /
Transgenomic

Comprehensive genetic test for
cardiac channelopathies and
cardiomyopathies

Approved and
marketed

Assays for mutations in
Factor V (Leiden) and
Factor II (prothrombin)
genes/Hologic Inc

Mutations in these genes are
associated with deep vein
thrombosis and pulmonary
embolism

Approved by the FDA

IL-1 gene expression/
Interleukin Genetics

To identify patients at high risk
for heart disease

Exploratory research

To provide drug targets for preventing
heart disease

Nanocheck ™ /Nano-Ditech
Corporation

Provides qualitative measurements
of three different well-known
cardiac biomarkers simultaneously
or separately
for detection of AMI: cTnI,
CK-MB and myoglobin

Available in
20 countries round
the world

qPCR-based for
mtDNA/Transgenomics

To detect mtDNA damage for
predicting CHD

In development

Triage BNP Test/Biosite
Inc

Protein chip quantitative fully
automated test based on
ADVIA Centaur ® BNP assay for
measurement of BNP in CHF

Available outside of
USA

Triage latex-agglutination
D-Dimer Test/Biosite
Inc

Portable and easy-to-use POC test
that can be used in the emergency
department or at the patients'
bedside for detection of pulmonary
embolism

Marketed

© Jain PharmaBiotech