Biology Reference
In-Depth Information
q 1
H
H
N
H
N
H
O
r 1
q 2
q 2
N
N
N
G-8
G-8
N
H
N
C-3
N
H
O
N
N
r 2
r 2
q 3
q 3
N
N
N
H
N
U-3
O
O
H
N
r 3
r 3
H
WT , k rel = 1
O
C3U , k rel » 3 ´ 10 - 4 to 0.02
N
A-8
N
N
q 1
H
q 3
O
O
H
N
r 1
N
N
H
r 3
q 2
N
N
N
H
G-3
C-8
N
N
H
N
C-3
N
r 2
q 3
N
H
N
N
H
O
r 3
H
H
G8A , k rel < 4 ´ 10 - 3
C3G/G8C , k rel » 0.004 to 0.8
O
O
q 2
q 2
N
N
N
N
U-3
A-8
N
H
N
I-8
N
H
N
C-3
r 2
N
N
r 2
q 3
q 3
N
N
O
N
H
O
H
N
r 3
r 3
H
H
G8I , k rel » 0.5 to 0.68
C3U/G8A , k rel » 0.012 to 0.5
O
q 1
q 1
H
H
N
N
H
O
N
H
N
C-3
r 1
r 1
q 2
q 2
N
N
N
U-3
D-8
N
H
N
D-8
N
H
N
N
r 2
N
r 2
q 3
H
N
N
O
N
H
N
H
r 3
H
H
C3U/G8D , k rel not available
G8D , k rel » 10 - 3
Figure 2.11 Schematic representations of the mutants and the hydrogen bonding net-
work of the C3 and G8 positions. k rel is the experimental cleavage constant relative to
the wild type. The relevant references are listed in Table 2.13 .
Previous Page
Next Page
Progress in Molecular Biology and Translational Science
Search WWH ::




Custom Search
Home