HDV Family of Self-Cleaving Ribozymes - Progress in Molecular Biology and Translational Science - page 151

A B

3

U A

3

10

10

A

A U

G
U
G
U
G

C

A U

G
A
G
A

30 30

C
U
U
C
U

A
C
A
G

C G C G

P2 P2

C G U A

60

G U U G

P1

G C

P1

G C

G C G C

C A

A

G C G C

1

1

U A

G U C

G

G
C
U

G U

5

5 P3 P3

HO

HO

G C

G C A C G U G C A C G U G C

P1.1 P1.1

A
A
G
C

A
A
U
C

60

U U U U U

20

C

20

J4/2 J4/2

J1.1/4

A 40

C G

U

53

C G

57

A

40

G
A

C

50

U A

P4 P4

U
A

G C

U G G

C

G A A A

50

G

U

C

C D

3 3

10

U
G
G
A
A

C

A C

G
G
G
C
A

U

G A

30

10

A
C
C
U

C
C
C
G

C G

U A

G C

C G

30

U A

P2 P2

A U

U A

P1 P1

15

C G G C

U

A U U

G C

U A

1

C G

G C G U

5

5 P3 P3

HO

HO

G C C G

G C C C G U C G G C A C G U C G

P1.1 P1.1

A
G
U
C 67

A
A
C
C

70

G C U G C U

60

U

20

20

J1.1/4

J4/2 J4/2

A

G G

A G

58

40

U
G

A
U

40

U
G

A
U

G A

C U

G C C G

P4 P4

U A

A

A U

A

U

U

60

G C C

G

50

A
U

C

U U

U

G
A

U

50

U A

C G

UU

Figure 4.9 Secondary structures for the (A) drz-Spur-1, (B) drz-Spur-2, (C) drz-Spur-3,
and (D) drz-Spur-4 ribozymes. Both drz-Spur-1 and drz-Spur-3 are found associated with
predicted reverse transcriptase genes, suggesting a role in retrotransposition for these
sequences.