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absorption of high-energy, short-wavelength light, lutein and zeaxanthin may reduce the amount
of light in the blue region of the spectrum that reaches the photosensitizers that are responsible for
light damage to the retina (Bone et al., 1997). More directly, these carotenoids may also serve as
antioxidants (Khachik et al., 1997).
ACKNOWLEDGMENTS
This work was supported by NEI grant EY12951, the Kaplen Fund, and unrestricted funds to the
Department of Ophthalmology, Columbia University from Research to Prevent Blindness.
REFERENCES
Ben-Shabat, S., Parish, C.A., Vollmer, H.R., Itagaki, Y., Fishkin, N., Nakanishi, K., Sparrow, J.R., 2002.
Biosynthetic studies of A2E, a major l uorophore of RPE lipofuscin. J Biol Chem . 277, 7183-7190.
Bhosale, P., Larson, A.J., Frederick, J.M., Southwick, K., Thulin, C.D., Bernstein, P.S., 2004. Identii cation and
characterization of a Pi isoform of glutathioine S-transferase (GSTP1) as a zeaxanthin-binding protein in
the macula of the human eye. J Biol Chem . 279, 49447-49454.
Bhosale, P., Zhao da, Y., Bernstein, P.S., 2007. HPLC measurement of ocular carotenoid levels in human donor
eyes in the lutein supplementation era. Invest Ophthalmol Vis Sci . 48, 543-549.
Birnbach, C.D., Jarvelainen, M., Possin, D.E., Milam, A.H., 1994. Histopathology and immunocytochemistry
of the neurosensory retina in fundus l avimaculatus. Ophthalmology . 101, 1211-1219.
Bone, R.A., Landrum, J.T., Friedes, L.M., Gomez, C.M., Kilburn, M.D., Menendez, E., Vidal, I., Wang,
W., 1997. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res . 64,
211-218.
Bone, R.A., Landrum, J.T., Fernandez, L., Tarsis, S.L., 1988. Analysis of the macular pigment by HPLC:
Retinal distribution and age study. Invest Ophthalmol Vis Sci . 29, 843-849.
Bunt-Milam, A.H., Kalina, R.E., Pagon, R.A., 1983. Clinical-ultrastructural study of a retinal dystrophy. Invest
Ophthalmol Vis Sci . 24, 458-469.
Fishkin, N., Sparrow, J.R., Allikmets, R., Nakanishi, K., 2005. Isolation and characterization of a retinal pig-
ment epithelial cell l uorophore: An all- trans -retinal dimer conjugate. Proc Natl Acad Sci U S A . 102,
7091-7096.
Grimm, C., Wenzel, A., Williams, T.P., Rol, P.O., Hafezi, F., Reme, C.E., 2001. Rhodopsin-mediated blue-light
damage to the rat retina: Effect of photoreversal of bleaching. Invest Ophthalmol Vis Sci . 42, 497-505.
Hammond, B.R., Johnson, E.J., Russell, R.M., Krinsky, N.I., Yeum, K.J., Edwards, R.B., Snodderly, D.M., 1997.
Dietary modii cation of human macular pigment density. Invest Ophthalmol Vis Sci . 38, 1795-1801.
Jang, Y.P., Matsuda, H., Itagaki, Y., Nakanishi, K., Sparrow, J.R., 2005. Characterization of peroxy-A2E and
furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cells
lipofuscin. J Biol Chem . 280, 39732-39739.
Junghans, A., Sies, H., Stahl, W., 2001. Macular pigments lutein and zeaxanthin as blue light i lters studied in
liposomes. Arch Biochem Biophys . 391, 160-164.
Khachik, F., Bernstein, P.S., Garland, D.L., 1997. Identii cation of lutein and zeaxanthin oxidation products in
human and monkey retinas. Invest Ophthalmol Vis Sci . 38,1802-1811.
Kim, S.R., He, J., Yanase, E., Jang, Y.P., Berova, N., Sparrow, J.R., Nakanishi, K., 2007a. Characterization of
dihydro-A2PE: An intermediate in the A2E biosynthetic pathway. Biochemistry 46, 10122-10129.
Kim, S.R., Jang, Y.P., Jockusch, S., Fishkin, N.E., Turro, N.J., Sparrow, J.R., 2007b. The all-trans-retinal dimer
series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.
Proc Natl Acad Sci U S A . 104, 19273-19278.
Krinsky, N.I., 2002. Possible biologic mechanisms for a protective role of zanthophylls. J Nutr . 132,
540S-542S.
Landrum, J.T., Bone, R.A., 2001. Lutein, zeaxanthin and the macular pigment. Arch Biochem Biophys . 385,
28-40.
Landrum, J.T., Bone, R.A., Joa, H., Kilburn, M.D., Moore, L.L., Sprague, K.E., 1997. A one year study of the
macular pigment: The effect of 140 days of a lutein supplement. Exp Eye Res . 65, 57-62.
Liu, J., Itagaki, Y., Ben-Shabat, S., Nakanishi, K., Sparrow, J.R., 2000. The biosynthesis of A2E, a l uorophore
of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment mem-
brane. J Biol Chem . 275, 29354-29360.
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