Biomedical Engineering Reference
In-Depth Information
Fig. 5. Induce dynamic changes in DNA crosslinked hydrogels. (
A
) Addition of DNA
crosslinks the hydrogel and upon delivery of adenosine which competitively binds to the
crosslinker DNA, resulting in the reverse of gelation (a) as demonstrated in the transition
from solution (b) to gel (c) and then back to solution (d). Extracted from (Yang et al. 2008)
with publisher's permission. (
B
) DNA hydrogel capable of capturing and releasing
thrombin based on thrombin-aptamer interactions. The end structure of DNA side chain A
has high affinity to thrombin to form thrombin-aptamer complex (Ba), which can be capture
