Biomedical Engineering Reference
In-Depth Information
and corneal protein markers (aggrecan and laminin) in lyophilized APCs repopulated with
cells grown
in vivo
for 1 week support the importance of recellularization of graft before
transplantation. These findings were more remarkable in lyophilized APC treated with
substance-P, which implicated the possible role of substance-P in stromal cell maturation in
cornea. Lamellar keratoplasty using lyophilized APC containing cells grown
in vivo
and
stimulated with substance-P had good graft survival without rejection for 8 weeks. These
results might provide a valuable clinical input to xenotransplantation using porcine cornea,
and lyophilized APC with cells grown
in vivo
might be useful for ocular surface
reconstruction.
6. Acknowledgement
This study was supported by a grant of the Korea Healthcare technology R&D Project,
Ministry for Health, Welfare & Family Affairs, Republic of Korea. (A084721)
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