Biomedical Engineering Reference
In-Depth Information
confirmed that silicon released from the materials results in a significant up-regulation of
osteoblast proliferation and gene expression [26,43,44]. The faster rate of degradation may
in fact provide the space and environment for matrix deposition and tissue growth [45],
and, at the same time, the quicker release Si ions from MBG/silk scaffolds may stimulate
the viability of osteoblast around the defects, to the benefit of
in vivo
osteogenesis. (3) One
cannot overlook the beneficial role that the stable pH environment of MBG/silk scaffolds
has on
in vivo
osteogenesis [46,47].
(a)
(b)
200µm
500µm
(c)
(d)
500µm
200µm
Fig. 14. Immunohistochemical analysis by Collagen I staining on the new bone tissues. (a)
and (b): MBG/silk; (c) and (d): BG/silk. (b) and (d) are higher magnification images [33].
3. Conclusion
In summary, we have successfully developed scaffolds containing MBG and silk
components for the purpose of bone tissue engineering. Two approaches in scaffold
fabrication have been investigated, namely silk surface-coating for MBG scaffolds and MBG
integrated silk scaffold.
