Biomedical Engineering Reference
In-Depth Information
(b)
(a)
(c)
(d)
Fig. 12. Micro-CT analysis for the
in vivo
bone formation of MBG/silk (a), BG/silk (b), silk
(c) scaffolds, and new bone volume (d) after implanted in calvarial defects of SCID mice for
8 weeks [33].
Immunohistochemical analysis revealed type I collagen (COL1) expression in the
de novo
bone in both MBG/silk and BG/silk scaffolds (Fig. 14); there was certainly slightly strong
COL1 expression in the bone matrix of the MBG/silk scaffolds (Fig. 14a and b) and this
expression was discernibly stronger compared to that in the BG/silk scaffolds (Fig. 14c and
d) [33].
