Biomedical Engineering Reference
In-Depth Information
Secondly, for nerve regeneration, it is suggested that blending a synthetic and natural
polymer (e.g. poly-e-caprolactone and collagen) is the best choice for Schwann cell seeding
to regenerate the spinal cord injuries, considering all results using different materials and
the mentioned criteria for an appropriate scaffold. The two suggested polymers have the
potential to play role of a scaffold in SCs seeding.
Collagen is a protein of ECM and exists in the basal membrane of the cell. It is easily
purified, which can be proposed as a proper substance; however, collagen has less strength
to withstand long time, support force adhesion, and degrades enzymatically within short
periods. Therefore, using another polymer such as PCL to enhance the stability and
mechanical strength of collagen would be crucial. In this sence, an excellent scaffold for
Schwann cell adhesion, migration, orientation, and proliferation can be provided.
Also electrospinning is considered as the excellent method for the fabrication of such
scaffolds. Additionally, electrospun nanofibers exhibit excellent supports for nerve growth
because they can provide large surface area to volume ratios, pore sizes tailored to Schwann
cells dimensions, functionalized surfaces, and multiple sites for interaction and attachment,
and low mass transfer limitation.
5. References
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