Biomedical Engineering Reference
In-Depth Information
6. Conclusions
Polyurethanes are very versatile polymers that found application in the biomedical field, es‐
pecially in cardiovascular applications. In spite of their good physicochemical and mechani‐
cal properties and acceptable biocompatibility they are prone to degradation under different
conditions. These conditions range from hydrolysis, oxidation, metal induced oxidation, en‐
vironmental stress cracking, enzyme-assisted degradation, etc. which can be found
in vivo
during the useful life of the device. In order to simulate these,
in vitro
approaches has been
followed. Thanks to this information today it is well accepted that polyurethanes are no lon‐
ger inert materials placed within the body. However, this disadvantage can be used to mod‐
ulate their degradation to a rate that can be controlled mainly by their composition, and be
used in the design of tissue engineering scaffolds.
Acknowledgements
This work was supported by CONACYT (México) Grant 79371, and Fondo Mixto CONA‐
CYT-Gobierno del Estado de Yucatán, Grants 108160 and 170132.
Author details
Juan V. Cauich-Rodríguez, Lerma H. Chan-Chan, Fernando Hernandez-Sánchez and
José M. Cervantes-Uc
Centro de Investigación Científica de Yucatán A.C., Grupo de Biomateriales e Ingeniería de
Tejidos, Mexico
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