Autograft of Dentin Materials for Bone Regeneration - Advances in Biomaterials Science and Biomedical Applications - page 392

grafting has been becoming a realistic alternative to the bone grafting in Korea. We have
thought the non-functional teeth as native resources of various graft materials and have ach‐
ieved the medical recycle of patient-own teeth as novel materials for bone regeneration in Ja‐
pan and Korea. This matrix-based bone therapy is Dental Innovation early in 21 st century. Our
innovative technique will expand from East Asia to the world.
BMPs, FGFs: matri x -binding proteins in NCPs. OCN: mineral-binding proteins in NCPs; Collagen: mainly type I collagen
Figure 1. Chemical components (w/v%) of human dentin and bone;
2. Biochemistry of human dentin
Dentin and bone are mineralized tissues and almost similar in chemical components. They
consist of body fluid, collagen, non-collagenous proteins (NCPs) and hydroxyapatite (HAp)
in weight volume (Fig. 1). The NCPs in dentin and bone are secreted into the ECM in the
process of biomineralization. The category is termed the SIBLING (Small Integrin-Binding
Ligand, N-linked Glycoprotein) family that includes dentin sialophosphoprotein (DSPP),
dentin matrix protein 1 (DMP1), bone sialoprotein (BSP) and osteopontin (OPN) (Fisher et
al, 2001; Qin et al, 2007; Sun et al, 2010; Qin et al, 2011).