Biology Reference
In-Depth Information
Figure 1.10, cont'd
frequencies were compiled from systematic searches of published literature,
personal communications and sources obtained through previously pub-
lished databases (
Mourant et al., 1976
;
Cavalli-Sforza et al., 1994
). Surveys
dating back to 1950, when the blood group was first described (
Cutbush
and Mollison, 1950
), were included. Results were refined so that only
population-based surveys were used and potentially biased samples were
removed. Survey data were geopositioned following guidelines described
previously by MAP (
Guerra et al., 2007
).
In addition to the frequency of the blood group variants, the diag-
nostic method used in each survey was recorded to classify the type of
information provided to ultimately inform the model. The Duffy antigen
has two main variant forms, Fy
a
and Fy
b
. These differ by a single amino
acid substitution (Gly42Asp), which is encoded in two alleles,
FY
*
A
and
