Diagnosis and Treatment of Plasmodium vivax Malaria - Advances in Parasitology - page 218

Table 4.2 Early Evidence for Quinine Synergizing Pamaquine against Relapse of
Chesson Strain Vivax Malaria Reported in 1947
Total dose
pamaquine (mg)

QN administration Number of subjects % relapse

240 Consecutive 1 100

420 Consecutive 5 100

434 Consecutive 7 100

882 Consecutive 5 100

240 Concurrent 5 80

420 Concurrent 5 60

630 Concurrent 5 60

882 Concurrent 5 40

Adapted from Craige et al. (1947a)

Table 4.3 Early Evidence for Quinine Synergizing Pamaquine against Relapse of
Chesson Strain Vivax Malaria Reported in 1948
Total dose
pamaquine

QN administration Number of subjects % relapse

None N/A 5 80

420 Concurrent 4 50

840 Concurrent 18 11

1260 Concurrent 4 0

1260 Consecutive 5 40

Adapted from Berliner et al. (1948b)

Table 4.4 Early Evidence of Quinine Synergizing Pamaquine against Relapse of St.
Elizabeth Strain Vivax Malaria Reported in 1949
Total dose
pamaquine

QN administration Number of subjects % relapse

360 Consecutive 6 33

360 Concurrent 6 0

720 Concurrent 7 0

1080 Concurrent 6 0

Adapted from Ruhe et al. (1949)

and the same dose of primaquine. Table 4.5 summarizes the findings. Pri-
maquine therapy concurrent with quinine achieved good efficacy (1 in 19
relapsed), whereas when administered consecutively, most of the volunteers
(15 of 19) relapsed. Quinine synergized the activity of primaquine against
relapse as did chloroquine but to a lesser degree (5 of 19 relapsed). Alving