Biology Reference
In-Depth Information
Figure 2.2
The temporal pattern of illness recurrence in patients with neurosyphilis
artificially infected for malaria therapy with
Plasmodium falciparum
(87 patients) and
the extensively studied 'Madagascar' strain of
P. vivax
(105 patients) studied by SP James
et al. at the Horton Hospital, Epsom, England (
James, 1931a
;
James et al., 1936
;
James
and Shute, 1926
) between 1925 and 1930. The vivax relapses had a bimodal pattern
with the majority having a long-latent period (mode 28 weeks) before the relapse. For
colour version of this igure, the reader is referred to the online version of this topic.
the induced infection, and so would have been genetically homologous.
In contrast, in endemic areas, multiple inoculations take place and relapses
can arise from parasites, which are genetically different (heterologous), and
were inoculated before the inoculation which caused the incident infection
and were presumably activated by it (
White, 2011
). Boyd and Kitchen, who
studied the McCoy strain in Florida, showed that (homologous) relapse did
not follow infections which had terminated spontaneously (indicating an
effective immune response) or infections, in which the primary illness lasted
