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In-Depth Information
the etiology of many human diseases such as cancer. Cancer cells show both
genome-wide hypomethylation and aberrant hypermethylation of CpG
islands (
Sandoval & Esteller, 2012
), as well as abnormal patterns of 5hmC
(
Jin, Jiang, et al., 2011
). The causal role of cytosine modifications in cancer
has become even more evident with the discovery that mutations in enzymes
that methylate (DNMT3A) and hydroxymethylate (TET2) DNA are
frequent in leukemia (
Delhommeau et al., 2009; Ley et al., 2010
). Therefore,
deciphering the role and regulation of DNA methylation and hydro-
xymethylation in development will also be instrumental in understanding
epigenetic deregulation in disease, which can ultimately lead to the develop-
ment of novel strategies and drugs that target the epigenome.
ACKNOWLEDGMENTS
Research in our laboratory is supported by the Centre National de la Recherche Scientifique
(CNRS), the University of Strasbourg, the ATIP-AVENIR program, the Agence Nationale
de la Recherche, the PNRPE program, and the EpiGeneSys network of Excellence.
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