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Table 9.1 Genome-wide studies of oocyte and sperm DNA methylation patterns in mouse
Oocyte
gDMRs in
CGIs
Oocyte CGI
gDMRs in
blastocysts
Global %
methylation
Genomic
distribution
% Oocyte CGI
in blastocysts
Study
Technique Coverage
Oocyte methylation
Smallwood
et al. (2011)
RRBS
>
5
15
40% promoter; 50%
intragenic; 10%
intergenic
962
207
21.5
Kobayashi
et al. (2012)
Bisul-Seq 70% at 1
; 40% at
40
Intragenic
1329
817
61.5
5
(avg. 18.8
)
Smith et al.
(2012)
RRBS
10
for a single
32
Intragenic CGI
promoters
376
(100 bp
tiles)
NP
NP
>
CpG;
5
for
>
100 bp tiles
Sperm
gDMRs in
CGIs
Sperm CGI
gDMRs in
blastocysts
Global %
methylation
Genomic
distribution
% Sperm CGI
in blastocysts
Study
Technique Coverage
Sperm methylation
Smallwood
et al. (2011)
RRBS
5
25
14% promoter; 74%
intragenic; 12%
intergenic
58
35
60.3
>
Kobayashi
et al. (2012)
Bisul-Seq 80% at 1
; 63% at
90
Intergenic; intragenic
349
34
9.7
5
(avg. 12.5
)
Smith et al.
(2012)
RRBS
10
for a single
83
Intergenic Repeat
elements
4894
(100 bp
tiles)
NP
NP
>
CpG;
5
for
>
100 bp tiles
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